Proteasome inhibition,the pursuit of new cancer therapeutics,and the adaptor molecule p130Cas |
| |
| Authors: | Dharminder Chauhan Kenneth C Anderson |
| |
| Institution: | 1.The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology,Dana Farber Cancer Institute, Harvard Medical School,Boston,USA |
| |
| Abstract: | Current interest in proteasome inhibitors for cancer therapy has stimulated considerable research efforts to identify the molecular pathway to their cytotoxicity with a view to identifying the mechanisms of sensitivity and resistance as well as informing the development of new drugs. Zhao and Vuori describe this month in BMC Biology experiments indicating a novel role of the adaptor protein p130Cas in sensitivity to apoptosis induced not only by proteasome inhibitors but also by the unrelated drug doxorubicin.See research article: http://www.biomedcentral.com/1741-7007/9/73 |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
