Indirect inactivation of tyrosinase in its action on tyrosine |
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Authors: | Muñoz-Muñoz Jose Luis Garcia-Molina Francisco Acosta-Motos Jose Ramon Arribas Enrique Garcia-Ruíz Pedro Antonio Tudela Jose Garcia-Cánovas Francisco Rodríguez-López Jose Neptuno |
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Institution: | GENZ: Grupo de Investigación Enzimología, Departamento de Bioquímica y Biología Molecular-A, Universidad de Murcia, Espinardo, Murcia, Spain. |
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Abstract: | Under aerobic conditions, tyrosinase is inactivated by dopa as a result of suicide inactivation, and, under anaerobic conditions, as a result of irreversible inactivation. However, tyrosine protects the enzyme from being inactivated by dopa under anaerobic conditions. This paper describes how under aerobic conditions the enzyme acting on tyrosine is not directly inactivated but undergoes a process of indirect suicide inactivation provoked by reaction with the o-diphenol originated from the evolution of o-dopaquinone and accumulated in the reaction medium. |
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