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Selenium supplementation influences growth performance, antioxidant status and immune response in lambs
Authors:N Kumar  AK Garg  RS Dass  VK Chaturvedi  V Mudgal  VP Varshney
Institution:aMineral and Vitamin Nutrition Laboratory, Centre of Advanced Studies in Animal Nutrition, Indian Veterinary Research Institute, Izatnagar 243122 (UP), India;bDivision of Bacteriology and Mycology, Indian Veterinary Research Institute, Izatnagar 243122 (UP), India;cDivision of Physiology and Climatology, Indian Veterinary Research Institute, Izatnagar 243122 (UP), India
Abstract:To investigate and compare the effect of inorganic and organic Se supplementation, 18 male lambs (24.68 ± 2.89 kg mean body weight, about 8–9 months of age) were divided into three groups of six animals in each, following randomized block design. While animals in the control group (Gr I) were fed a standard TMR containing 195 g/kg crushed maize grain, 175.5 g/kg soybean meal, 260 g/kg wheat bran, 13 g/kg mineral mixture (without Se), 6.5 g/kg common salt and 350 g/kg wheat straw, animals in Gr II and Gr III were additionally supplemented with 0.15 mg Se/kg of diet through sodium selenite (inorganic Se) and Jevsel-101 (organic Se), respectively. Experimental feeding was done for a period of 90 days. To assess the humoral immune response, all the lambs were intramuscularly inoculated with a single dose (2 mL) of Haemorrhagic septicaemia oil adjuvant vaccine on day 0; and blood samples were collected on day 0, 30, 60 and 90. Supplementation of Se had no effect on serum total cholesterol, total protein, albumin, globulin, albumin:globulin ratio, T3, T4, T4:T3 ratio; serum Ca and P levels and SGOT and SGPT activity. However, there was a significant increase in the serum Se level, RBC GSH-Px activity and humoral immune response in both the Se supplemented groups as compared to control group. Average daily gain (g) was highest (110) in Gr III, followed by Gr II (98.2) and lowest in Gr I (89.1). Thus, supplementation of organic as well as inorganic Se was found to improve the growth rate, humoral immune response and antioxidant status of the lambs; and between two sources, organic Se was more effective than inorganic Se.
Keywords:Lambs  Selenium  Growth  Antioxidant status  Blood metabolites  Immunity
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