N-terminal amino acid sequence analysis indicates that isolated atrial amyloid is derived from atrial natriuretic peptide |
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| Authors: | R P Linke C Voigt F S St?rkel M Eulitz |
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| Affiliation: | Institut für Immunologie der LM-Universit?t, München, Federal Republic of Germany. |
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| Abstract: | Isolated atrial amyloid, the most frequent senile cardiac amyloid type, was chemically analysed. Amyloid fibrils obtained from a patient (NIP) were extracted and the predominant low-molecular-weight polypeptide (approximately 3.5 kDa, designated ASc2 NIP) was isolated by size exclusion high performance liquid chromatography in 60% formic acid. N-Terminal amino acid sequence analysis of this polypeptide was identical to that of the atrial natriuretic peptide alpha-hANP for the first 12 residues determined. |
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