Ethanol-induced Adaptation of Alcohol Dehydrogenase Activity in Rat Brain |
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| Authors: | NEIL H. RASKIN LOUIS SOKOLOFF |
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| Affiliation: | 1.Department of Neurology,University of California School of Medicine,San Francisco;2.Laboratory of Cerebral Metabolism,National Institute of Mental Health,Bethesda |
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| Abstract: | ALTHOUGH the presence of alcohol dehydrogenase (ADH) in cerebral tissue has been established1, a physiological role for such a brain ethanol-oxidizing system has been unclear. The brain may be more biochemically adaptive than was once thought2; thus, it seemed possible that brain ADH may be substrate-induced. We now report that significant elevations of brain ADH activity occur in alcohol-imbibing rats; no changes from control values were found in liver ADH, liver aldehyde dehydrogenase (AldDH), or brain AldDH activities. |
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