Control of histone acetylation : Cell-cycle dependence of deacetylase activity in Physarum nuclei |
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Authors: | Jaap H Waterborg Harry R Matthews |
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Institution: | Department of Biological Chemistry, School of Medicine, University of California, Davis, CA 95616, USA |
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Abstract: | Nuclei from naturally synchronous plasmodia of Physarum polycephalum were assayed for histone deacetylase activity. The substrate for the assay was a peptide comprising the amino terminal region (residues 1–23) of calf thymus histone H4. The deacetylase activity per nucleus remained constant during S phase and early G2 phase and then doubled in a linear fashion during mid and late G2 phase reaching its maximum level at metaphase. The data imply that H4 acetylation is linked to prior chromatin structural changes. |
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