Expression of stromal-derived factor-1 is decreased by IL-1 and TNF and in dermal wound healing |
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| Authors: | Fedyk E R Jones D Critchley H O Phipps R P Blieden T M Springer T A |
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| Affiliation: | Center For Blood Research, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. |
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| Abstract: | Stromal-derived factor-1 (SDF-1) is a CXC chemokine that is believed to be constitutively expressed by stromal cells of numerous tissues. In this report, we demonstrate that dermal fibroblasts and vessels of noninflamed tissues express SDF-1. Unexpectedly, we found that expression of SDF-1 is regulated by inflammation. Expression of SDF-1 by primary cultures of human gingival fibroblasts is potently inhibited by activated macrophages via secretion of IL-1alpha and TNF-alpha. Levels of SDF-1 mRNA also decrease in acutely inflamed mouse dermal wounds. We propose that SDF-1 functions as a homeostatic regulator of tissue remodeling, whose expression stabilizes existing dermal architecture. |
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