Increase of estrogen receptor level by thyroxine in estrogen dependent pituitary tumor (MtT/F84) in rats |
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Authors: | N Fujimoto B Roy H Watanabe A Ito |
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Institution: | Department of Cancer Research, Hiroshima University, Japan. |
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Abstract: | A rat transplantable pituitary tumor, MtT/F84, grows much faster in E2 treated rats than in normal females, but is much retarded in thyroidectomized rats. Triiodothyronine (T3) administration in a drinking water increased the tumor growth by the dose dependent manner. The tumor contained both estrogen receptor (ER) and T3 receptor. ER levels both in the nuclei and cytosols elevated 2 to 3 times by the T3 administration compared to those of control. E2 administration promotes the growth of MtT/F84 through elevation of nuclear ER level. T3 may directly elevate cellular ER level and thus it may enhance estrogenic actions including the tumor growth. |
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