Design and synthesis of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancer |
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| Authors: | Li Yu Zhang Hui-Bin Huang Wen-Long Li Yun-Man |
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| Institution: | Center of Drug Discovery, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, Jiangsu 210009, China. |
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| Abstract: | Exploration for new MDR-modulator utilizing tetrahydroisoquinoline as scaffold disclosed 6,7-dimethoxy-1-(3,4-dimethoxy)benzyl-2-(N-n-octyl-N'-cyano)guanyl-1,2,3,4-tetrahydroisoquinoline (7) as a readily accessible medicinal lead. Compound 7 possessed potent MDR reversal activity in the range of the reference compound verapamil, and had not cardiovascular activity compared to verapamil. |
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