Continuous Treatment with Morphine Increases Diazepam Binding Inhibitor mRNA in Mouse Brain |
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Authors: | Masashi Katsura Atsuo Hara Atsuko Higo Chihaya Tarumi Yasushi Hibino Seitaro Ohkuma |
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Affiliation: | Department of Pharmacology, Kawasaki Medical School, Kurashiki;and; Department of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto, Japan |
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Abstract: | Abstract: Effects of acute and chronic morphine treatment on the expression of diazepam binding inhibitor (DBI) mRNA in the mouse brain were examined. Cerebral DBI mRNA expression significantly increased in morphine-dependent mice, and this increase is more remarkable in morphine-withdrawn mice, whereas a single administration of morphine (50 mg/kg) produced no changes in the expression. Simultaneous administration of naloxone (3 mg/kg) with morphine completely abolished the increase in cerebral DBI mRNA expression observed in morphine-dependent and -withdrawn mice. These results indicate that a chronic functional interaction between morphine and opioid receptors has a critical role in increases in DBI mRNA expression. |
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Keywords: | Diazepam binding inhibitor Mouse cerebral cortex Morphine dependence Morphine withdrawal Opioid receptors |
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