Gene-Dependent Effect of Lithium on Circadian Rhythms in Mice (Mus Musculus) |
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Authors: | Bernard Possidente Robert H Exner |
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Institution: |
a Department of Biology, Skidmore College Saratoga Spring, NY, USA |
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Abstract: | Lithium has been shown to lengthen free-running circadian periods in a variety of species. Here we show that lithium carbonate differentially lengthens the free-running period of a circadian wheel running rhythm in BALB/CByJ and C57BL/10Sn inbred mouse strains. This result supports previous evidence that lithium lengthens mammalian circadian rhythms, and also demonstrates that gene differences can mediate individual differences in response to lithium treatment. |
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Keywords: | Circadian rhythm lithium inbred strain Mus musculus |
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