Aromatic amino acids in amniotic fluid samples analyzed by reversed-phase liquid chromatography with spectrophotometric detection |
| |
| Authors: | Ant M. Krstulovic,Salvatore Ciriello |
| |
| Affiliation: | Chemistry Department, Manhattanville College, Purchase, N.Y. 10577 U.S.A.;Catecholamine Research Laboratory, Department of Medicine, The Mount Sinai School of Medicine, City University of New York, New York, N.Y. 10029 U.S.A. |
| |
| Abstract: | The applicability of threshold logic units, a form of nonparametric pattern recognition, to the processing of metabolic profile data obtained by high-efficiency glass capillary column gas chromatography has been investigated. The test data included profiles of the volatile constituents of urine from normal individuals and from individuals with diabetes mellitus. A feature extraction algorithm allowed for dimensionality reduction and indicated the constituents most important in the normal versus pathological distinction. With an optimum number of dimensions, a normal versus pathological prediction rate of 93.75% was achieved. Gas chromatography—mass spectrometry was utilized to identify important profile constituents. |
| |
| Keywords: | To whom correspondence should be addressed |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
