Ganglioside Composition in Human Meningiomas |
| |
Authors: | Pia Davidsson Pam Fredman V Peter Collins Hans von Hoist† Jan-Eric Mansson Lars Svennerholm |
| |
Institution: | Department of Psychiatry and Neurochemistry, Gothenburg University, St. J?rgen Hospital, Hisings Backa, Sweden. |
| |
Abstract: | The ganglioside composition in meningioma specimens from 20 patients was analyzed to find potential meningioma-associated structures. The characterization was performed by immunological staining with specific monoclonal antibodies to ganglioside antigens and fast atom bombardment-mass spectrometry. The major gangliosides were GM3 and GD3, and most of the meningioma specimens could be divided into a "GM3-rich" or a "GD3-rich" group. Gangliosides of the gangliotetraose series were represented by GM1, GD1a, GD1b, and GT1b, which were found in minor amounts in all the specimens. The ratios of GM1/GD1a and GD1a/GD1b differed from that in normal brain, and therefore existence of this series could not be explained by contamination with brain material. Ganglioside 3'-isoLM1, found in human malignant glioma, could not be detected in any meningioma specimen. |
| |
Keywords: | Ganglioside GangJioside antigen Human Meningioma |
|
|