Ataxia telangiectasia: the effects of chemical mutagens and x-rays on sister chromatid exchanges in blood lymphocytes |
| |
Authors: | S M Galloway |
| |
Affiliation: | MRC Clinical and Population Cytogenics Unit, Western General Hospital, Crewe Road, Edinburgh Scotland |
| |
Abstract: | It is now possible to examine in detail exchanges between sister chromatids (SCEs) and to attempt to investigate the relationships of such exchanges to aberration formation and DNA-repair mechanisms. The frequency of SCEs is dramatically increased by chemical mutagens and may reflect the level of DNA damage. Lymphocytes from patients with ataxia telangiectasis (AT) show high levels of spontaneous chromosome damage and are hypersentive to ionising radiations and it was of interest to examine the levels of SCE induced in these cells by various mutagens. The frequencies of SCE after treatment with X=rays or three chemical mutagens were equivalent to those in normal cells. The effects of fluorodeoxyuridine and deoxycytidine on SCE frequencies were also tested. |
| |
Keywords: | AM Adriamycin AT Ataxia telangiectasia Brd U 5-bromodeoxyuridine dCyd deoxycytidine EMS ethyl methanesulphonate FA Fanconi's anemia FUdR 5-fluorodeoxyuridine MMC mitomycin C SCE sister-chromatid exchange UdR uridine XP xeroderma pigmentosum |
本文献已被 ScienceDirect 等数据库收录! |