Simulation of Pulmonay Damages Induced by Inhaled CL2 on the Bronchial Tree |
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Authors: | Pierre F Baconnier Catherine Marey Ahmed Ménaouar |
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Institution: | (1) Laboratoire PRETA/TIMC/IMAG, Université Joseph Fourier, 38706 La Tronche, France |
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Abstract: | We have measured the change of lung mechanical parameters on isolated rabbit lungs exposed to chlorine gas (Cl{in2}). Experimental
results show parallel increase in elastance and resistance of impaired lungs. We tried to determine whether this may be explained
by a reduction of the ventilated areas in the lung, consecutive to closure of some airways. We have then tried to simulate
these experimental results by studying the effects of various airways occlusions imposed on two concurrent models (symmetrical
and dissymmetrical) of the tracheo-bronchial tree. For each model, we successively evaluated the resistance of the normal
lung, simulated a partial peripheral airways occlusion and estimated the induced changes in total resistance. Analytical expressions
of the "occluded lung" elastance and resistance have been found for the symmetrical model but not for the dissymmetrical model
(a graphical approach is proposed). With the symmetrical model, simulated results are comparable to experimental ones when
the occlusion level is proximal. Whatever the dissymmetry level (δ) of the fractal tree model, we could not simulate the expected
increase in resistance with the observed increase in elastance. We conclude that either the occlusion is non homogeneous or
the lung impairment is not only a reduction in ventilated areas.
This revised version was published online in June 2006 with corrections to the Cover Date. |
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