Small, non-peptide C5a receptor antagonists: part 2 |
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| Authors: | Blagg Julian Mowbray Charles Pryde David Salmon Gary Fairman David Schmid Esther Beaumont Kevin |
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| Affiliation: | Department of Discovery Chemistry, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. |
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| Abstract: | Starting from 2, several highly potent C5a receptor antagonists were synthesised through alpha-amide substitution. Attempts to increase the polarity of these compounds through the introduction of basic centres or incorporation into weakly basic heterocycles is described. |
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