Molecular and Cellular Evidence for an Oligodendrocyte Abnormality in Schizophrenia |
| |
Authors: | Hof Patrick R. Haroutunian Vahram Copland Christina Davis Kenneth L. Buxbaum Joseph D. |
| |
Affiliation: | (1) Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY;(2) Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY;(3) Department of Psychiatry, Mount Sinai School of Medicine, New York, NY |
| |
Abstract: | Our previous analyses in postmortem prefrontal cortex samples from a well-characterized cohort of severely affected schizophrenics and in matched controls demonstrated decreased expression of myelin and oligodendrocyte-related genes in the disease state. This decreased expression, now replicated in independent studies, suggests that there is a disruption of oligodendrocyte function and/or a loss of oligodendrocytes in schizophrenia. In the current report, we review expression studies in schizophrenia and present data demonstrating consistently fewer oligodendrocytes in schizophrenics compared to controls. The decrease in density reached 22% (p < 0.01) in layer III of area 9 and 20% (p < 0.02) in the white matter of the superior frontal gyrus. These data, when taken together with expression studies carried out by us and by other groups, and by imaging and other microscopic studies, point to a major involvement of oligodendrocyte abnormalities in schizophrenia. Therapies modulating oligodendrocyte survival and differentiation may therefore be beneficial in schizophrenia. |
| |
Keywords: | Schizophrenia oligodendrocyte myelin microarray stereology therapeutics |
本文献已被 PubMed SpringerLink 等数据库收录! |
|