Synthesis, characterization and biological evaluation of some 16E-arylidene androstane derivatives as potential anticancer agents |
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| Authors: | Guo Hao Wu Haotian Yang Jin Xiao Yuling Altenbach Hans-Josef Qiu Guofu Hu Hao Wu Zhongyuan He Xianran Zhou Dingshan Hu Xianming |
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| Institution: | a State Key Laboratory of Virology, College of Pharmacy, Wuhan University, Wuhan 430072, China
b Bergische Universität Wuppertal, FB 9 - Organische Chemie, Gauss-Str. 20, 42097 Wuppertal, Germany |
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| Abstract: | A series of new 16E-arylidene androstane derivatives were synthesized and characterized. The new compounds were screened for their anticancer activities against the human cancer cell lines SW480, A549, HepG2 and HeLa in vitro using the MTT assay. The results of the in vitro study showed that a number of compounds have shown IC50 values lower than 20 μM against the four cancer cell lines. |
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| Keywords: | 16E-arylidene androstane Heterocycles Synthesis Anticancer activity |
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