Sea urchin deciliation induces thermoresistance and activates the p38 mitogen-activated protein kinase pathway |
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Authors: | Casano Caterina Roccheri Maria Carmela Maenza Luisa Migliore Silvia Gianguzza Fabrizio |
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Institution: | Dipartimento di Biologia Cellulare e dello Sviluppo "A. Monroy," Università di Palermo, Viale delle Scienze, Parco D'Orleans, 90128 Palermo, Italy. |
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Abstract: | In this study, we demonstrate by a variety of approaches (ie, morphological analysis, Western blots, immunolocalization, and the use of specific antibodies) that hyperosmotic deciliation stress of sea urchin embryos induces a thermotolerant response. Deciliation is also able to activate a phosphorylation signaling cascade the effector of which might be the p38 stress-activated protein kinase because we found that the administration of the p38 inhibitor SB203580 to sea urchin deciliated gastrula embryos makes the hyperosmotic deciliation stress lethal. |
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