Rapid murine mixed lymphocyte cultures assessed by emergence of T-cell insulin receptors |
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| Authors: | Terry B Strom J Harold Helderman R Michael Williams |
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| Institution: | (1) Department of Medicine, Harvard Medical School, Peter Bent Brigham Hospital, USA;(2) Department of Medicine, University of Texas Health Science Center, 75235 Dallas, Texas;(3) Division of Tumor Immunology, Sidney Farber Cancer Institute, Harvard Medical School, USA |
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| Abstract: | Murine T lymphocytes incubated in a mixed lymphocyte culture with allogeneic lymphocytes incompatible for theH-2 region or subregions thereof rapidly develop insulin receptors. In contrast, T cells cultured with syngeneic orH-2- andMlslocus compatible cells do not develop insulin-binding sites. The emergence of insulin receptors is probably an early premitotic event. |
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