Novel substituted 4-aminomethylpiperidines as potent and selective human beta3-agonists. Part 2: arylethanolaminomethylpiperidines |
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| Authors: | Steffan Robert J Ashwell Mark A Solvibile William R Matelan Edward Largis Elwood Han Stella Tillet Jeffery Mulvey Ruth |
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| Affiliation: | Chemical Sciences, Wyeth Research, 500 Arcola Rd, Collegeville, PA 19426, USA. steffar@wyeth.com |
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| Abstract: | The synthesis and SAR of a series of beta3 adrenoreceptor agonists based on a novel template derived from 4-aminomethylpiperidine coupled with a common pharmacophore, arylethylamine, is described. This combination led to the identification of human beta3 adrenoreceptor agonists with in vivo activity in a transgenic mouse model. |
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