Rat liver metabollothionein interactions of silver,zinc, and cadmium |
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Authors: | P. D. Whanger J. T. Deagen |
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Affiliation: | (1) Department of Agricultural Chemistry, Oregon State University, 97331 Corvallis, Oregon |
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Abstract: | Weanling rats were fed diets either alone or with combinations of silver, elevated zinc, or elevated cadmium for 7 weeks. The rats were then killed, and the silver, zinc, and cadmium proteins isolated from the livers by gel filtration and ion exchange chromatography. When silver was fed alone in diet, low levels of this metal were eluted as two peaks from the ion exchange column. In contrast, when silver was fed with cadmium or elevated zinc, three metal-containing peaks were eluted from this ion exchange column. Amino acid analysis revealed that the major proteins binding these metals are metallothioneins, as judged by high cysteine content. |
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Keywords: | Metallothionein, interactions of Cd, Ag, and Zn cadmium, interactions with Ag and Zn, in metallothionein silver, interactions with Cd and Zn, in metallothionein zinc, interactions with Cd and Ag, in metallothionein rat liver interactions of Ag, Cd, and Zn in liver, rat, interactions of Cd, Ag, and Zn in |
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