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Rat liver metabollothionein interactions of silver,zinc, and cadmium
Authors:P D Whanger  J T Deagen
Institution:(1) Department of Agricultural Chemistry, Oregon State University, 97331 Corvallis, Oregon
Abstract:Weanling rats were fed diets either alone or with combinations of silver, elevated zinc, or elevated cadmium for 7 weeks. The rats were then killed, and the silver, zinc, and cadmium proteins isolated from the livers by gel filtration and ion exchange chromatography. When silver was fed alone in diet, low levels of this metal were eluted as two peaks from the ion exchange column. In contrast, when silver was fed with cadmium or elevated zinc, three metal-containing peaks were eluted from this ion exchange column. Amino acid analysis revealed that the major proteins binding these metals are metallothioneins, as judged by high cysteine content.
Keywords:Metallothionein  interactions of Cd  Ag  and Zn  cadmium  interactions with Ag and Zn  in metallothionein  silver  interactions with Cd and Zn  in metallothionein  zinc  interactions with Cd and Ag  in metallothionein  rat liver  interactions of Ag  Cd  and Zn in  liver  rat  interactions of Cd  Ag  and Zn in
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