Metabolic products of microorganisms. 185. The anthraquinones of the Aspergillus glaucus group. I. Occurrence,isolation, identification and antimicrobial activity |
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Authors: | Heidrun Anke Itham Kolthoum Hans Zähner Hartmut Laatsch |
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Institution: | (1) Lehrbereich Mikrobiologie I, Institut für Biologie II, Auf der Morgenstelle 28, D-7400 Tübingen, Federal Republic of Germany;(2) Organisch-Chemisches Institut der Universität, Tammannstr. 2, D-3400 Göttingen, Federal Republic of Germany |
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Abstract: | The occurrence of emodin, erythroglaucin, physcion, physcion-9-anthrone, questin, catenarin, and catenarin-8-methyl ether in different species of the Aspergillus glaucus group (genus Eurotium) was investigated. So far catenarin-8-methyl ether (1, 4, 6-trihydroxy-8-methoxy-3-methylanthraquinone) has not been described as a natural product; it was therefore given the name rubrocristin. The chemical and physical properties of rubrocristin are reported. In addition a new violet pigment (C16H12O5) was isolated and characterized by its MS-, IR- and UV-spectra.The antimicrobial properties of all substances were examined in the agar diffusion assay. Gram-positive bacteria were the most sensitive organisms and catenarin was the most active naturally occurring substance. Synthetically obtained 1, 4, 6, 8-tetrahydroxy-anthraquinone was slightly more active than catenarin, whereas rubrocristin showed no antibacterial activity.Abbreviations MIC
Minimal inhibitory concentration
- TLC
Thin layer chromatography
- PTLC
Preparative thin layer chromatography
Metabolic products of microorganisms. 184. H. Anke: On the mode of action of cladosporin. J. Antibiotics 32, 952–958 (1979) |
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Keywords: | Antibiotics from Aspergilli Emodin Erythroglaucin Physcion Physcion-9-anthrone Questin Catenarin Rubrocristin Anthraquinones |
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