The effect of organic toxicants on sensitivity of intestinal glycosidases to Cu and Zn in juvenile roach |
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Authors: | A. A. Filippov I. L. Golovanova |
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Affiliation: | 1.Papanin Institute of the Biology of Inland Waters,Russian Academy of Sciences,Borok, Nekouzskii raion, Yaroslavl oblast,Russia |
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Abstract: | The chronic effect (duration of exposure 218 days) of polychlorinated biphenyls (PCBs) and the prolonged effect of the short-term action of chlorophos or of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) during embryogenesis upon the sensitivity of intestinal glycosidases to Cu and Zn was studied in roach (Rutilus rutilus (L.) underyearlings. The Cu+2 and Zn+2 ions at concentrations ranging from 0.1 to 25 mg/L in vitro cause a 10–77% decrease in amylolytic activity in the intestinal mucosa of control roach. An elevated level of PCBs (50.8 ng/g wet weight of food and 426 ng/g dry weight of ground) increased the sensitivity of glycosidases to Cu and Zn. The embryotoxic action of chlorophos at concentrations of 1 × 10−6−1 × 10−2 mg/L in most cases increased the inhibitory effect of Cu but decreased that of Zn. As a rule, MNNG (3 × 10−7−3 × 10−1 mg/L) reduced the glycosidase sensitivity to the effect of metal ions. The magnitude and direction of the effect depend on the nature and concentration of toxicants. |
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