|
|||||
|
|
Radiation hybrid mapping of the canine type I and type IV collagen gene subfamilies |
|
| Authors: | Jennifer?K?Lowe Richard?Guyon Melissa?L?Cox Dianne?C?Mitchell Amy?L?Lonkar Frode?Lingaas Catherine?André Francis?Galibert Elaine?A?Ostrander |
| Institution: | (1) Department of Molecular and Cellular Biology, University of Washington, Seattle, WA 98115, USA;(2) Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., D4–100 , Seattle, WA 98109, USA;(3) Génétique et Développement, Faculté de Médecine, UMR6061 CNRS, 2 Avenue du Professeur Léon Bernard, 35043 Rennes, France;(4) Department of Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843, USA;(5) Department of Animal Science, Texas A&M University, College Station, TX 77843, USA;(6) Department of Microbiology and Molecular Cell Sciences, University of Memphis, Memphis, TN 38152, USA;(7) Department of Animal Genetics, Norwegian College of Veterinary Medicine, 0035 Oslo, Norway |
| Abstract: | We are interested in the collagen gene superfamily and its involvement in hereditary diseases of the human and domestic dog. Presented here is radiation hybrid mapping of the type I and type IV collagen gene subfamilies on the most recent version of the canine map. The col1A1 gene was mapped to chromosome 9, col1A2 was mapped to chromosome 14, col4A1 and col4A2 were mapped to chromosome 22 and col4A3 and col4A4 were mapped to chromosome 25. The col4A5 and col4A6 genes, while linked to one another, are not linked in the present version of the canine map but likely are present on the X chromosome. These data provide an insight into the molecular evolution of these subfamilies and increase the number of mapped genes in discrete regions of the canine genome. J.K. Lowe and R. Guyon contributed equally to this work Sequences determined during the course of this work have been deposited in GenBank. Accession numbers are AF291995 (col1A1) and AF291996 (col1A2) |
| Keywords: | Dog Integrated map Gene families Collagen |
| 本文献已被 PubMed SpringerLink 等数据库收录！ | |