Serum selenium versus lymphocyte subsets and markers of disease progression and inflammatory response in human immunodeficiency virus-1 infection |
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Authors: | Markus P Look Jürgen K Rockstroh Govind S Rao Karl A Kreuzer Ulrich Spengler Tilman Sauerbruch |
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Institution: | (1) Department of General Internal Medicine, University of Bonn, Sigmund Freud-Strasse 25, 53105 Bonn, Germany;(2) Institute for Clinical Biochemistry, University of Bonn, Sigmund Freud-Strasse 25, 53105 Bonn, Germany |
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Abstract: | Serum selenium levels were determined cross-sectionally in 57 HIV-infected patients who were classified according to the Centers
for Disease Control (CDC) 1993 classification system. Mean serum selenium levels were lower in CDC stage II (58.7±12.2 μg/L;p<0.01;n=18) and stage III (47.6±11.3 μg/L;p<0.01;n=19) HIV-infected patients, than in healthy subjects (80.6±9.6 μg/L;n=48) and stage I patients (73.6±16.5 μg/L;n=20). Serum selenium levels were positively correlated with CD4 count, CD4/8 ratio, hematocrit, and serum albumin (r=0.42;r=0.39;r=0.48; andr=0.45;p<0.01, respectively) and inversely with serum levels of thymidine kinase (r=−0.49;p<0.01;n=49) and β2-microglobulin (r=−0.46;p<0.001;n=49). In addition, serum selenium levels in 20 randomly selected AIDS-free individuals (CDC I:n=10; CDC II:n=10) were inversely correlated with serum concentrations of interleukin-8 (IL-8) and soluble tumor necrosis factor receptors
(sTNFR) types I and II. There was no correlation with serum immuneglobulin A and total serum protein levels. The results show
that the progressive deprivation of serum selenium in HIV-infection is associated with loss of CD4+-cells and with increased levels of markers of disease progression and inflammatory response. |
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Keywords: | AIDS HIV-infection serum selenium thymidine kinase β 2-microglobulin interleukin-8 soluble tumor necrosis factor receptors I and II |
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