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Oleanane-type triterpene oligoglycosides with pancreatic lipase inhibitory activity from the pericarps of Sapindus rarak |
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| Authors: | Toshio Morikawa Yuanyuan Xie Yasunobu Asao Masaki Okamoto Chihiro Yamashita Osamu Muraoka Hisashi Matsuda Yutana Pongpiriyadacha Dan Yuan Masayuki Yoshikawa |
| Affiliation: | a Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan b School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Wenhua Rd., Shenyang 110016, People’s Republic of China c Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan d Faculty of Science and Technology, Rajamangala University of Technology, Srivijaya, Thungyai, Nakhonsithammarat 80240, Thailand |
| Abstract: | The methanolic extract from the pericarps of Sapindus rarak DC. was found to show pancreatic lipase inhibitory activity (IC50 = ca. 614 μg/mL). From the extract, oleanane-type triterpene oligoglycosides, rarasaponins I–III (1–3), and raraoside A (4), were isolated together with 13 known saponins and four known sesquiterpene glycosides. Among them, several saponin constituents including rarasaponins I (1, IC50 = 131 μM) and II (2, 172 μM), and raraoside A (4, 151 μM) inhibited pancreatic lipase activity, which were stronger than that of theasaponin E1 (270 μM). |
| Keywords: | Sapindus rarak Sapindaceae Thai natural medicine Oleanane-type triterpene oligoglycoside Pancreatic lipase inhibitor |
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