New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix |
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Authors: | Murakami Nobutoshi Ye Ying Kawanishi Motoyuki Aoki Shunji Kudo Nobuaki Yoshida Minoru Nakayama Emi E Shioda Tatsuo Kobayashi Motomasa |
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Institution: | Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, Japan. |
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Abstract: | Bioassay-guided separation by use of the fission yeast expressing NES of Rev, a HIV-1 viral regulatory protein, resulted in isolation of valtrate (1) as a new Rev-transport inhibitor from the nucleus to cytoplasm from Valerianae Radix. Valtrate (1) also inhibited the p-24 production of HIV-1 virus without showing any cytotoxicity against the host MT-4 cells. |
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