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Phenylacetyl group as enzyme-cleavable aminoprotection of purine nucleosides |
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| Authors: | M.A. Dineva B. Galunsky V. Kasche D.D. Petkov |
| Affiliation: | Lab. Biocatalysis, Institute of Organic Chemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria a AB Biotechnologie II, Technische Universität Hamburg-Harburg, 21071 Hamburg, FRG |
| Abstract: | N6-Phenylacetyl-2′-deoxyadenosine and N2-Phenylacetyl-2′-deoxyguanosine are readily deprotected in reactions catalyzed by free and immobilized penicillin amidase at pH 7.8 and 25°C. |
| Keywords: | N-phenylacletyl protection nucleosides nucleotide synthesis penicillin amidase |
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