Detection of mutagenic pollution of natural environment using microbiological assays |
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| Authors: | Wegrzyn G Czyz A |
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| Institution: | Department of Molecular Biology, University of Gdańsk, Kładki, Gdańsk, Poland;, Institute of Oceanology, Polish Academy of Sciences, Św. Wojciecha, Gdynia, Poland;, and Laboratory of Molecular Biology (affiliated with the University of Gdańsk), Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Kładki, Gdańsk, Poland |
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| Abstract: | One of the most important and serious ecological problems is mutagenic pollution of the natural environment. Therefore, detection of mutagenic compounds in samples taken from natural habitats is of special interest. Microbiological mutagenicity tests seem to be very useful tools for such detection. In this review article, a general view on the tests employing genetically modified bacterial strains designed for detection of low concentrations of mutagenic compounds is presented. Moreover, a comparison of advantages and disadvantages of selected assays, developed early on and more recently, and features of these assays are discussed. It appears that none of the currently available mutagenicity tests is perfect or optimal for all purposes. Thus, a choice for the particular assay must depend on the nature of studies and specific tasks of the experiments to be performed. |
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