A protein inhibitor of rabbit liver phosphorylase phosphatase. |
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Authors: | H Brandt E Y Lee S D Killilea |
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Affiliation: | Department of Biochemistry University of Miami Miami, Florida 33152 USA |
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Abstract: | Extracts of rabbit liver contain a heat-stable, non-dialysable inhibitor of phosphorylase phosphatase. The inhibitory activity is destroyed by trypsin treatment or by ethanol precipitation. The kinetics of the inhibition are non-competitive with respect to phosphorylase a. The inhibitory activity is polydisperse on gel permeation chromatography. The mechanism of the inhibition is due to a direct interaction of the protein inhibitor with the enzyme. |
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