The effect of the immunization of animals with a live plague vaccine on the lysosome count in organ-specific macrophages

Vital fluorochromatic lysosomes of peritoneal, liver, splenic and lung macrophages of white mice, white rates, and guinea-pigs are studied. Reliable differences in a quantity of lysosomal granules of macrophages from various tissues as well as differences between macrophages from the same tissues of different experimental animals are found. At 21 days after animal immunization with live plague vaccine EV the most significant changes in the number of lysosomal granules are revealed in white mice. The number of lysosomes in guinea pigs increased in 1 and 7 days after vaccination, in 14 days their number became normal.