Involvement of p38 Mapkinase in attenuation of antinociceptive effect of morphine in diabetic mice |
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Authors: | Gilhotra Neeraj Sharma Ajay Singh Manjeet |
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Institution: | Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147 002, India. neeraj_gilhotra@yahoo.co.in |
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Abstract: | Experimental diabetes induced by streptozotocin (200 mg/kg, ip) markedly decreased the antinociceptive effect of morphine and significantly increased the urinary nitrite concentration. Administration of FR-167653 (a selective p38MAPKinase inhibitor) in a dose of 4 mg/kg improved the antinociceptive effect of morphine and attenuated the increase in urinary nitrite concentration in diabetic mice. It may be concluded that diabetes-induced decrease in antinociceptive effect of morphine may be due to induction of p38 MAPKinase activity. |
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