Periodic,multimodal distribution of granule volumes in mast cells |
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Authors: | Hammel Ilan Lagunoff David Bauza Michael Chi Emil |
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Affiliation: | 1.Department of Pathology, St. Louis University, School of Medicine, St. Louis, Missouri, USA ;2.Department of Pathology, University of Washington, School of Medicine, Seattle, Washington, USA ; |
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Abstract: | The areas of 2327 mast cell granules in transmission electron micrographs of sections of peritoneal mast cells from adult rats were measured by digitized planimetry. A histogram constructed using equivalent volumes calculated from the measured areas assuming approximation of the granules to spheres showed a periodic multimodal distribution in which the modes fell at volumes that were successively larger integral multiples of the volume at the first mode. Application of a moving-bin technique to the data confirmed the presence of the modes. We propose a mechanism of fusion of unit sized granules to account for the multimodal distribution. The presence of pear- and dumbbell-shaped granules in mast cells is consistent with this mechanism. |
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