Effect of b-c1-site inhibitors on the midpoint potentials of mitochondrial cytochromes b |
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Authors: | W S Kunz A A Konstantinov |
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Affiliation: | 1. Institut für Physiologische Chemie, Medizinische Akademie Magdeburg, Leipziger Str. 44, Magdeburg, GDR;2. A.N. Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University, Moscow, 117234, USSR |
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Abstract: | Anaerobic potentiometric titrations of b cytochromes have been carried out in beef heart submitochondrial particles in the presence of several specific inhibitors of electron transfer through the b-c1-site of the respiratory chain. Whereas antimycin shows no significant effect on the titration curve of cytochrome b-562, NoHOQnO is found to shift the Em of b-562 by 20-30 mV to the positive. Funiculosin raises the Em of b-562 by greater than 100 mV and also appears to bring about a minor shift of b-566 midpoint potential. In the presence of myxothiazol, both b cytochromes titrate with Em values 15-30 mV more positive than in the control. |
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Keywords: | Respiratory chain Redox titration Funiculosin Myxothiazol HpHOQnO NoHOQnO SMP submitochondrial particles |
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