Hydroxytyrosol lipophilic analogues: enzymatic synthesis, radical scavenging activity and DNA oxidative damage protection |
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| Authors: | Grasso Salvatore Siracusa Laura Spatafora Carmela Renis Marcella Tringali Corrado |
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| Institution: | Dipartimento di Chimica Biologica, Chimica Medica e Biologia Molecolare, Università di Catania, Viale A. Doria 6, 95125 Catania, Italy. |
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| Abstract: | The olive oil phenol hydroxytyrosol (3), as well its metabolite homovanillic alcohol (4), were subjected to chemoselective lipase-catalysed acylations, affording with good yield 10 derivatives (5-14) bearing C(2), C(3), C(4), C(10) and C(18) acyl chains at C-1. Hydroxytyrosol (3) and its lipophilic derivatives showed very good DPPH. radical scavenging activity. Compounds 3, 4 and their lipophilic analogues 5-14 were subjected to the atypical Comet test on whole blood cells: 3 and its analogues 5 and 6, with little hydrophobic character (logP
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| Keywords: | Hydroxytyrosol Homovanillic alcohol Lipophilic analogues Radical scavenging DNA damage protection Comet assay Antioxidants |
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