Effects of bilobalide on amino acid release and electrophysiology of cortical slices |
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| Authors: | Jones F A Chatterjee S S Davies J A |
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| Affiliation: | (1) Department of Pharmacology, Therapeutics and Toxicology, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom, GB;(2) Department of Pharmacology, Arzneimittel, Dr Willmar Schwabe GmbH & Co., Karlsruhe, Germany, DE |
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| Abstract: | Summary. This study investigated the effects of bilobalide, a constituent of Ginkgo biloba, on potassium and veratridine-induced release of glutamate and aspartate from mouse cortical slices. We also studied its effects on spontaneous and N-methyl-D-aspartate (NMDA)-induced depolarizations elicited in magnesium-free artificial cerebrospinal fluid (aCSF) as well as its effect on NO-711 (a γ-aminobutyric acid (GABA) uptake inhibitor)-induced depolarizations. Bilobalide, 100 μM significantly reduced both glutamate and aspartate release elicited by potassium or veratridine. Bilobalide (5–100 μM) also significantly reduced the frequency of NO-711 induced depolarizations, however, it had no effect on spontaneous or on NMDA-induced depolarizations at 5–200 μM. These results suggest that the neuroactive properties of bilobalide may be mediated by a reduction in excitatory amino acid neurotransmitter release. Received June 25, 2001 Accepted October 4, 2001 |
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| Keywords: | : Amino acids Bilobalide Mouse cortical slices Glutamate Depolarizations |
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