Import of proteins into mitochondria |
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Authors: | M Eilers K Verner S Hwang G Schatz |
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Affiliation: | Biocentre, University of Basle, Switzerland. |
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Abstract: | A mounting body of evidence suggests that cytoplasmically synthesized proteins destined to be imported into the mitochondrial interior must at least partly unfold to penetrate across the mitochondrial membranes. During post-translational import, this unfolding process appears to be a major rate-limiting step. It can be blocked by ligands that stabilize the protein's native conformation and appears to be accompanied by the cleavage of ATP outside the mitochondrial inner membrane. |
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