Intracellular angiotensin II disrupts chemical communication and impairs metabolic cooperation between cardiac myocytes |
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| Institution: | 1. Global Research Center for Innovative Life Science, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan;2. Laboratory of Regulatory Biology, Graduate School of Science and Engineering, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan;1. Department of Human Molecular Genetics and Biochemistry, Sackler Medical School, Adams Super Center for Brain Studies & Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel;2. Department of Natural and Life Sciences, The Open University, Raanana, Israel;1. Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, P.O. Box 70577, Johnson City, TN 37614, USA;2. Walgreen''s Pharmacy, Colonial Heights, TN 37663, USA;3. North Alabama ENT Associates, Huntsville, AL 35801, USA;1. Department of Health and Human Services, National Cancer Institute, Center for Cancer Research, Office of the Director, Bethesda, MD 20892, USA;2. National Institute of Diabetes, Digestive, and Kidney Disease, Digestive Diseases Branch, Bethesda, MD 20892, USA |
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| Abstract: | The influence of intracellular angiotensin II (Ang II) on the process of chemical communication and metabolic cooperation between cardiac cells is discussed. Emphasis is given to the influence of pathological conditions like heart failure, myocardial ischemia or hyperglycemia on the activation of the intracrine renin angiotensin aldosterone system (RAAS) and its consequence for the metabolic cooperation between heart cells. Furthermore, the influence of high glucose on the process of chemical communication was described as well as its implication for the failing and diabetic heart. The major conclusion is that the activation of the intracrine renin angiotensin induced by heart failure, hyperglycemia, aldosterone or myocardial ischemia generates metabolic imbalance in the heart with serious consequences for the cardiac function. |
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| Keywords: | Intracellular angiotensin Chemical communication Heart cells |
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