The protective effect of apelin on ischemia/reperfusion injury |
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| Institution: | 1. Integrated Center of Cellular Therapy and Regenerative Medicine, International Clinical Research Center, St. Anne''s University Hospital, Brno, Czech Republic;2. Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA;3. Division of Engineering, Mayo Clinic, Rochester, MN 55905, USA;4. Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA;5. Department of Internal Medicine — Cardiology, Palacky University, Olomouc, Czech Republic;6. Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic |
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| Abstract: | Apelin is the endogenous ligand for the APJ, a member of the G protein coupled receptors family. Apelin/APJ system is widely distributed in central nervous system and peripheral tissues, especially in heart, lung and kidney. Apelin plays important physiological and pathological roles in cardiovascular system, immune system, neuroprotection, etc. This article outlines the protective effect of apelin on ischemia/reperfusion (I/R) injury. Apelin could activate multiple protective mechanisms to prevent heart, brain, liver and kidney I/R injury. Apelin/APJ system may be a promising therapeutic target for ischemic and other related diseases. |
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| Keywords: | Apelin APJ Ischemia/reperfusion injury Heart Brain |
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