Lipid involvement in protein translocation in Escherichia coli |
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| Authors: | G J de Vrije † A M Batenburg ‡ J A Killian B de Kruijff |
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| Institution: | Centre for Biomembranes and Lipid Enzymology, University of Utrecht, The Netherlands. |
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| Abstract: | Signal peptides play an essential role in protein translocation. This review summarizes the current knowledge of the structure of signal peptides and signal peptide-lipid interactions and addresses the possibility that signal peptide-lipid interactions initiate membrane translocation of precursor proteins. A new model for protein translocation in Escherichia coli is proposed, which includes as central features conformational changes of the signal peptide and signal-peptide-induced local changes in membrane organization (non-bilayer lipids). |
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