Urinary pepsinogen isozymes: A highly polymorphic locus in man |
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| Authors: | R T Taggart R C Karn A D Merritt P L Yu P M Conneally |
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| Institution: | (1) Department of Medical Genetics, Indiana University Medical Center, 46202 Indianapolis, IN, USA;(2) Department of Human Genetics, Yale University School of Medicine, 06510 New Haven, CT, USA |
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| Abstract: | Summary A genetic analysis of human urinary pepsinogen isozymes is presented. Nine discrete phenotypes were identified in a population survey of 215 unrelated Caucasian individuals. The phenotypes were characterized by differences among the staining intensities of the activated group I pepsinogens, Pg 5, Pg 4, Pg 3, and Pg 2. The genetic studies demonstrated that the codominant expression of four alleles, Pg
A, Pg
B, Pg
C and Pg
D, at a single genetic locus determined the nine phenotypes identified. Linkage analysis excluded close linkage of the Pg locus with the chromosome 6 markers HLA, GLO
1, and Bf. |
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| Keywords: | |
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