Effects of cholestyramine on 1,2-dimethylhydrazine-induced enteric carcinoma in germfree rats. |
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Authors: | T Asano M Pollard D C Madsen |
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Abstract: | Oral administration of 1,2-dimethylhydrazine (DMH) induced intestinal neoplasms in germfree rats. A supplement of 2% cholestyramine resin in the diet increased the frequency of DMH-induced intestinal tumors and accelerated malignant transformation. Bile acids in the cecal content were determined with and without cholestyramine in order to obtain a correlation between the bile acid metabolism and the enteric carcinogenesis. |
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