THE EFFECTS OF AGE AND ALCOHOL ON (Na++ K+)-ATPASE ACTIVITY OF WHOLE HOMOGENATE AND SYNAPTOSOMES PREPARED FROM MOUSE AND HUMAN BRAIN |
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| Authors: | A. Y. Sun T. Samorajski |
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| Affiliation: | Laboratory of Neurochemistry, Ohio Mental Health and Mental Retardation Research Center, Cleveland Psychiatric Institute, Cleveland, OH 44109, U. S. A. |
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| Abstract: | Whole homogenates of mouse brain and nerve-ending fractions of mouse and human brain were obtained at various age levels representative of maturity and old age. The mice were 3, 8 and 26–29 months old and the humans ranged in age from 19 to 84 y. Measurements of (Na++ K+)-ATPase in whole brain homogenate of mouse did not reveal any significant differences in relation to age. However, the ability of ethanol at various concentrations to inhibit membrane-bound synaptosomal (Na++ K+)-ATPase was significantly greater in older mice and humans. The data are interpreted as indicating a change in the property of synaptic membranes as a consequence of advancing age. |
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