|
|||||
|
|
Non-peptide oxytocin agonists |
|
| Authors: | Pitt Gary R W Batt Andrzej R Haigh Robert M Penson Andrew M Robson Peter A Rooker David P Tartar André L Trim Julie E Yea Christopher M Roe Michael B |
| Affiliation: | Ferring Research Ltd, Chilworth Science Park, Southampton SO16 7NP, UK. |
| Abstract: | A library of compounds targeted to the vasopressin/oxytocin family of receptors was screened for activity at a cloned human oxytocin receptor using a reporter gene assay. Potency and selectivity were optimised to afford compound 39, EC50 = 33 nM. This series of compounds represents the first disclosed, non-peptide, low molecular weight agonists of the hormone oxytocin (OT). |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ | |