Neural spike generator entrainment by regularly spaced synaptic input |
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Authors: | J R Harvey L J Bruner |
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Institution: | (1) Department of Physics, University of California, Riverside, CA 92521, USA, US |
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Abstract: | It has been known for 30 years that the output of a repetitively firing neuron or pacemaker can be synchronized (locked)
to regularly spaced inhibitory or excitatory postsynaptic input potentials. Conditions for stable locking have been determined
mathematically, demonstrated in computer simulation, and locking has been observed in vivo. We have developed a neural spike
generator circuit model which exhibits stable locking to externally derived simulated inhibitory or excitatory post-synaptic
inputs. Conditions for stable 1 : 1 lock, in which pacemaker output frequency matches that of the periodic input, are derived.
These take the form of expressions for stable delay and convergence factor which incorporate known or measurable parameters
of the circuit model. The expressions have been evaluated and shown to compare satisfactorily with experimental observations
of locking by our circuit model.
Received: 28 March 1996 / Accepted in revised form: 18 February 1997 |
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