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Probabilistic divergence measures for detecting interspecies recombination
Authors:Husmeier D  Wright F
Affiliation:Biomathematics & Statistics Scotland, SCRI, Invergowrie, Dundee, DD2 5DA, UK. dirk@bioss.ac.uk
Abstract:This paper proposes a graphical method for detecting interspecies recombination in multiple alignments of DNA sequences. A fixed-size window is moved along a given DNA sequence alignment. For every position, the marginal posterior probability over tree topologies is determined by means of a Markov chain Monte Carlo simulation. Two probabilistic divergence measures are plotted along the alignment, and are used to identify recombinant regions. The method is compared with established detection methods on a set of synthetic benchmark sequences and two real-world DNA sequence alignments.
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