Probabilistic divergence measures for detecting interspecies recombination |
| |
Authors: | Husmeier D Wright F |
| |
Affiliation: | Biomathematics & Statistics Scotland, SCRI, Invergowrie, Dundee, DD2 5DA, UK. dirk@bioss.ac.uk |
| |
Abstract: | This paper proposes a graphical method for detecting interspecies recombination in multiple alignments of DNA sequences. A fixed-size window is moved along a given DNA sequence alignment. For every position, the marginal posterior probability over tree topologies is determined by means of a Markov chain Monte Carlo simulation. Two probabilistic divergence measures are plotted along the alignment, and are used to identify recombinant regions. The method is compared with established detection methods on a set of synthetic benchmark sequences and two real-world DNA sequence alignments. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|