Enhancement of dissolution profile by solid dispersion (kneading) technique |
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Authors: | Aftab Modi Pralhad Tayade |
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Institution: | (1) Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz (E), 400 098 Mumbai, India;(2) Pharmaceutical Division, University Institute of Chemical Technology, University of Mumbai, Nathlal Parikh Marg, Matunga, 400 019 Mumbai, India |
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Abstract: | This article investigates enhancement of the dissolution profile of valdecoxib using solid dispersion with PVP. The article
also describes the preparation of fast-dissolving tablets of valdecoxib by using a high amount of superdisintegrants. A phase
solubility method was used to evaluate the effect of various water-soluble polymers on aqueous solubility of valdecoxib. Polyvinyl
pyrrolidone (PVP K-30) was selected and solid dispersions were prepared by the method of kneading. Dissolution studies, using
the USP paddle method were performed for solid dispersions of valdecoxib. Infrared (IR) spectroscopy, differential scanning
calorimetry (DSC), and x-ray diffractometry (XRD) were performed to identify the physicochemical interaction between drug
and carrier, hence its effect on dissolution. Tablets were formulated containing solid dispersion products and compared with
commercial products. IR spectroscopy, XRD, and DSC showed no change in the crystal structure of valdecoxib. Dissolution of
valdecoxib improved significantly in solid dispersion products (<85% in 5 minutes). Tablets containing solid dispersion exhibited
better dissolution profile than commercial tablets. Thus, the solid dispersion technique can be successfully used for improvement
of dissolution of valdecoxib.
Published: August 18, 2006 |
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Keywords: | Solid dispersion valdecoxib dissolution enhancement fast-dissolving tablets |
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