Effects of cell cycle specific exposure to 3H-thymidine or 3H-arginine on development and cell proliferation of mouse embryos |
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Authors: | W.-U. Müller N. Heckeley C. Streffer |
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Affiliation: | Institut für Medizinische Strahlenbiologie, Universit?tsklinikum Essen, D-45122 Essen, Germany, DE
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Abstract: | One-cell mouse embryos were exposed to either 3H-thymidine (100 or 200 kBq/ml) or 3H-arginine (2.5 to 50 kBq/ml) for 2 h either in G1, S or G2 phase. 3H-Arginine affected embryonic development and cell proliferation in an activity-dependent way irrespective of the cell cycle stage exposed, whereas 3H-thymidine was effective only at higher activities and only after exposure during S phase. Received: 12 July 1996 / Accepted in revised form: 30 September 1996 |
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